Silver Ring Pharma

Benzodiazepines possess sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant, and amnesic actions, which are useful in a variety of indications such as alcohol dependence, seizures, anxiety disorders, panic, agitation, and insomnia.

There are significant physical, mental and social risks associated with the long-term use of benzodiazepines. Although anxiety can temporarily increase as a withdrawal symptom, there is evidence that a reduction or withdrawal from benzodiazepines can lead in the long run to a reduction in anxiety symptoms.

Xanax is taken by mouth and is readily absorbed into the bloodstream. You should start feeling the effects of Xanax in under an hour. The medication reaches peak concentrations in the bloodstream in one to two hours following ingestion. People who take Xanax will often build up a tolerance.Nov 20, 2017

clorazepate (Tranxene)

chlordiazepoxide (Librium)

diazepam (Valium, Diastat Acudial, Diastat)

estazolam (Prosom is a discontinued brand in the US)

lorazepam (Ativan)

oxazepam (Serax is a discontinued brand in the US)

temazepam (Restoril)

triazolam (Halcion)

Oxazepam (Serax) has a slow onset, and lorazepam (Ativan), alprazolam (Xanax), and clonazepam (Klonopin) have intermediate onsets of action. Clorazepate (Tranxene), midazolam (Versed), and triazolam (Halcion) are short-acting agents with durations of action of 3 to 8 hours.

Depressants such as Xanax, Klonopin, Halcion and Librium are often referred to as “benzos” (short for benzodiazepines1). Other depressants, such as Amytal, Numbutal and Seconal, are classed as barbiturates—drugs that are used as sedatives and sleeping pills.

The elderly are especially sensitive to benzodiazepines. … In the present day, the benzodiazepine class, which also includes Ativan, Valium, Xanax, and Klonopin, is frequently prescribed for the treatment of anxiety and anxiety-related conditions.Aug 28, 2017

Researchers have long-known that benzodiazepines can cause brain damage. that benzodiazepines such as Valium and Xanax can cause brain damage.Nov 18, 2010

A high dose of benzodiazepines can cause a person to overdose. This means that a person has taken more benzodiazepines than their body can cope with. Higher doses of benzodiazepines can result in drowsiness, over-sedation and sleep. They may produce an effect similar to drinking a large amount of alcohol.

Benzodiazepines can be used to treat anxiety, seizures, and insomnia. … Panic attacks: Because of their fast-acting anti-anxiety effects, benzodiazepines are very effective at treating anxiety associated with panic disorder.Jan 5, 2018

Other common benzodiazepines include Xanax (alprazolam), Valium (diazepam), and Ativan (lorazepam). Klonopin and these other benzodiazepines can assist in decreasing the intensity of panic attacks and anxiety. Klonopin is commonly prescribed to treat panic disorder (with or without agoraphobia).Aug 28, 2018

However, they are much less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken; however, when combined with other central nervous system depressants such as alcohol and opiates, the potential for toxicity and fatal overdose increases.

Benzodiazepines and the law. Benzodiazepines can be prescribed by doctors and are legal if used as prescribed. It is illegal to use benzodiazepines without a prescription, or to give or sell them to other people.Dec 14, 2016

Xanax is a trade name for the anti-anxiety medication alprazolam. It is one of a group of addictive prescription medications known as benzodiazepines. Although Xanax is a prescription medication, it is also a controlled drug, which means it is illegal to take Xanax without a prescription from a medical doctor.Jun 24, 2018

Benzodiazepines are a type of medication known as tranquilizers. Familiar names include Valium and Xanax. They are some of the most commonly prescribed medications in the United States. When people without prescriptions obtain and take these drugs for their sedating effects, use turns into abuse.Apr 23, 2016

How Do Benzodiazepines Make You Feel? Low to moderate doses of benzodiazepines can relieve mild to moderate anxiety and make you feel relaxed and calm. Higher doses can relieve insomnia and severe states of emotional distress, and may make you feel drowsy and possibly clumsy. … The type of benzodiazepine you take.

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Examples of full agonists are heroin, oxycodone, methadone, hydrocodone, morphine, opium and others. An antagonist is a drug that blocks opioids by attaching to the opioid receptors without activating them. Antagonists cause no opioid effect and block full agonist opioids. Examples are naltrexone and naloxone.

Narcan. Narcan (naloxone) is an opioid antagonist used for the complete or partial reversal of opioid overdose, including respiratory depression. Narcan is also used for diagnosis of suspected or known acute opioid overdose and also for blood pressure support in septic shock. Narcan is available in generic form.

In pharmacology the term agonist-antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, behaves as an antagonist (a substance that binds to a receptor but does not …

Side effects. Naloxone has little to no effect if opioids are not present. In people with opioids in their system, it may cause increased sweating, nausea, restlessness, trembling, vomiting, flushing, and headache, and has in rare cases been associated with heart rhythm changes, seizures, and pulmonary edema.

Antagonist. An antagonist is the character or thing that is against the protagonist in a text. The antagonist is often thought of as the “bad guy,” but that may not be the case. The protagonist could be the bad person, and the antagonist is the person or thing that opposes him.

Suboxone can be detected through drug screening tests via blood, urine, or hair samples. RxList notes a half-life of 24-42 hours in the bloodstream for buprenorphine and just 2-12 hours for naloxone. Typical doses of buprenorphine are detectable in the urine for three days.

Opioids are natural or synthetic chemicals that reduce feelings of pain. Common prescription opioids include:

Hydrocodone (Vicodin®)

Oxycodone (OxyContin®)

Oxymorphone (Opana®)





No. Opioids pose a risk to all patients. Anyone taking prescription opioids is at risk for unintentional overdose or death and can become addicted. From 1999 to 2016, more than 200,000 people died from overdose related to prescription opioids in the United States.1 Up to 1 out of 4 people receiving long-term opioid therapy in a primary care setting struggles with opioid use disorder.2,3,4

In addition to the serious risks of opioid use disorder and overdose, the use of prescription opioids can have a number of side effects, even when taken as directed. Review these with your doctor, so you know what you may expect:

Tolerance—needing to take more of the medication over time for the same pain relief

Physical dependence—experiencing symptoms of withdrawal when the medication is stopped

Increased sensitivity to pain


Nausea and vomiting

Dry mouth

Sleepiness and dizziness



Low levels of testosterone that can result in lower sex drive, energy, and strength



Remember, your doctor is a partner in your pain treatment plan. It’s important to talk about any and all side effects and concerns to make sure you’re getting the safest and most effective care.

ofcourse there resources to help learn more about opioids bello are some web pages that will help you .These web pages will help you learn more about prescription opioids:

Opioid Basics

Commonly Used Terms

Helpful Materials for Patients

CDC’s Rx Awareness Campaign

When Narcan nasal spray is used, it also works within two to five minutes. The effects of Narcan last anywhere from half an hour to an hour. For some people, multiple doses are required, because the length of action of opioids is longer than naloxone’s duration of action.Sep 7, 2018

The antagonist of a story is the thing that throws obstacles in the way of the protagonist getting what he or she wants. Notice that I didn’t say “the person who throws obstacles in the way.” An antagonist can be a wide variety of things, not just a human or human-like villain.Apr 13, 2011

Naloxone will not work on a cocaine overdose, only opioid overdoses. If it is a cocaine overdose that also involves opioids, it might help by dealing with the opioid part of the OD. Cocaine overdoses are dangerous because they are not dose-dependent and they are a complicated medical emergency- call 911.

It is very dangerous to combine opioids with other drugs, especially those that cause drowsiness. Risk of opioid overdose and death increases at higher dosages, and when taken for longer periods of time or more often than prescribed.

Talk to your doctor about any other medications you are using. Work out a plan to call your doctor if you continue to experience pain. Also ask about the serious side effects (like excessive sleepiness or craving more of the medication) so you and your family know when to call a doctor or go to the hospital.

Anyone who takes prescription opioids can become addicted to them. You may also develop tolerance—meaning that over time you might need higher doses to relieve your pain, putting you at higher risk for a potentially fatal overdose. You can also develop physical dependence—meaning you have withdrawal symptoms when the medication is stopped.

Tell your doctor about your medical history and if you or anyone in your family has a history of substance misuse or addiction to drugs or alcohol. Also, never take opioids in higher amounts or more often than prescribed.

Naloxone typically has a shelf life of 18 -24 months. No. If you suspect an opioid overdose, it is safe to give naloxone. People who are dependent on opioids may wake up with withdrawal symptoms.

To use injectable naloxone:

Do rescue breathing for a few quick breaths if the person is not breathing.

Use a long needle: 1 – 1 ½ inch (called an IM or intramuscular needle)- needle exchange programs and pharmacies have these needles.

Pop off the orange top vial.

Draw up 1cc of naloxone into the syringe 1cc=1mL=100u.

Opioid medications are one of many ways to treat pain. It may be helpful to know that:

Acute pain: usually starts suddenly and has a known cause, like an injury or surgery. It normally gets better as your body heals.

Chronic pain: pain lasts 3 months or more and can be caused by a disease or condition, injury, medical treatment, inflammation, or even an unknown reason.

Prescription opioids can be used to treat severe acute pain, but there is no evidence that they are as effective for long-term use. If you’re prescribed an opioid, the best approach is to try the lowest possible dose in the smallest quantity. Opioids should only be used when necessary and only for as long as necessary. Generally, for acute pain this is often 3 days or less; more than 7 days is rarely needed.

Before taking opioid medication for chronic pain

Discuss with your doctor pain treatment options, including ones that do not involve prescription drugs.

Tell your doctor about your medical history and if you or anyone in your family has a history of substance misuse or addiction to drugs or alcohol.

Discuss all of the risks and benefits of taking prescription opioids.

Talking openly with your healthcare provider will help to make sure you’re getting care that is safe, effective, and right for you. Set up a follow-up appointment with your doctor to reevaluate your pain and, if you have been taking opioids for more than a few days, give you guidance on the best way to cope with possible withdrawal symptoms when you stop.

Flumazenil (Romazicon) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. Its use, however, is controversial as it has numerous contraindications.

Endorphins then bind to opioid receptors in the “reward center” of the brain, triggering the release of dopamine, a brain chemical responsible for the pleasurable effects of alcohol. Naltrexone prevents endorphins from taking effect by blocking off opioid receptors before any alcohol is consumed.Jun 28, 2018

Naloxone is a fairly stable medication, with a shelf life between 18 months and two years. IN and IM naloxone should be stored between 59 and 86 degrees Fahrenheit, and should be kept away from direct sunlight. In most law enforcement settings, naloxone can be stored in the cab of the vehicle.

None of the drugs currently available for benzodiazepine reversal, such as physostigmine, give consistent clinical results. The purpose of this paper is to discuss Flumazenil, a new specific benzodiazepine receptor antagonist, and its possible use for dental sedation procedures.

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