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Amphetamine and dextroamphetamine combination is used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or sudden attacks of deep sleep). These two medicines belong to the group of medicines called central nervous system (CNS) stimulants.
Amphetamine and dextroamphetamine combination works in the treatment of ADHD to increase attention and decrease restlessness in patients who are overactive, cannot concentrate, or are easily distracted. It is used as part of a total treatment program that also includes social, educational, and psychological therapy.
This medicine is available only with a doctor’s prescription. Prescriptions cannot be refilled. A new prescription must be obtained from your doctor each time you need this medicine.
This product is available in the following dosage forms:
Capsule, Extended Release
This combination medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Amphetamine/dextroamphetamine belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.
This drug is also used to treat a certain sleeping disorder (narcolepsy) to help you stay awake during the day. It should not be used to treat tiredness or to hold off sleep in people who do not have a sleep disorder.
How to use Adderall
Read the Medication Guide provided by your pharmacist before you start taking amphetamine/dextroamphetamine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually 1 to 3 times a day. The first dose is usually taken when you wake up in the morning. If more doses are prescribed, take them as directed by your doctor, usually 4-6 hours apart. Taking this medication late in the day may cause trouble sleeping (insomnia).
The dosage is based on your medical condition and response to treatment. Your doctor may adjust your dose to find the dose that is best for you. Follow your doctor’s instructions carefully.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
During treatment, your doctor may occasionally recommend stopping the medication for a short time to see whether there are any changes in your behavior and whether the medication is still needed.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (including severe tiredness, sleep problems, mental/mood changes such as depression) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed.
When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.
Tell your doctor if your condition does not improve or if it worsens.
Doses of Adderall are individualized, so your dose will depend on why you’re taking Adderall, and on your response to the drug.
Doctors usually start with a low dose and increase the amount gradually.
The best dose will be the lowest possible dose that works.
A child older than 5 who is taking Adderall for ADHD would typically start with a dose of 5 milligrams (mg) and increase it gradually to 30 mg.
A typical dose for an adult with narcolepsy may start at 5 mg and increase to 60 mg.
You can take Adderall and Adderall XR with or without food.
People usually take Adderall tablets every four to six hours during the day.
People take Adderall XR capsules once a day, in the morning. Adderall taken in the evening can interfere with sleep.
Guidelines call for swallowing capsules whole. Or, you can open the capsule and sprinkle the contents into a teaspoon of applesauce. It’s important to take any opened medicine right away.
Symptoms of an Adderall overdose may include:
Loss of consciousness
If you think you have taken an overdose or if someone else may have overdosed on Adderall, If you or someone else has symptoms of an overdose, call 9-1-1.
Missed Dose of Adderall
Take Adderall exactly as directed by the doctor.
Do not stop taking Adderall suddenly. This can cause severe depression, extreme tiredness, and other Adderall withdrawal symptoms.
If you miss a dose of Adderall, take the missed dose as soon as you remember.
But, if it’s almost time for the next dose, skip the missed dose.
Do not double the dose to make up for a missed dose.
Monoamine oxidase inhibitors (MAOIs) taken with amphetamine may result in a hypertensive crisis if taken within two weeks after last use of an MAOI type drug.
Inhibitors of enzymes that directly metabolize amphetamine (particularly CYP2D6 and FMO3) will prolong the elimination of amphetamine and increase drug effects.
Serotonergic drugs (such as most antidepressants) co-administered with amphetamine increases the risk of serotonin syndrome.
Stimulants and antidepressants (sedatives and depressants) may increase (decrease) the drug effects of amphetamine, and vice versa.
Gastrointestinal and urinary pH affect absorption and elimination. Gastrointestinal alkalizing (acidifying) agents increase (decrease) absorption. Urinary alkalizing (acidifying) agents increase concentration of non-ionized (ionized) species, decreasing (increasing) urinary excretion.
Proton-pump inhibitors (PPIs) modify the pharmacokinetics of Adderall XR and Mydayis. Co-administration requires monitoring for changes in clinical effect.
Zinc supplementation may reduce the minimum effective dose of amphetamine when it is used for the treatment of ADHD
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other sympathomimetic drugs (such as lisdexamfetamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (such as Raynaud’s disease), certain mental/mood conditions (such as severe agitation, psychosis), personal/family history of mental/mood disorders (such as bipolar disorder, depression, psychotic disorder, suicidal thoughts), heart problems (including irregular heartbeat/rhythm, coronary artery disease, heart failure, cardiomyopathy, problems with the heart structure such as valve problems), family history of heart problems (such as sudden death/irregular heartbeat/rhythm), history of stroke, high blood pressure, overactive thyroid (hyperthyroidism), a certain eye problem (glaucoma), seizures, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), personal or family history of uncontrolled muscle movements (such as Tourette’s syndrome), kidney disease, liver disease.
This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Children may be more sensitive to the side effects of this drug, especially weight loss. This medication may slow down a child’s growth. The doctor may recommend temporarily stopping the medication from time to time to reduce this risk. Monitor your child’s weight and height. Consult your doctor or pharmacist for more details.
Older adults may be more sensitive to the side effects of this drug, especially chest pain, trouble sleeping, or weight loss.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Infants born to mothers who are dependent on this medication may be born too soon (premature) and have low birth weight. They may also have withdrawal symptoms. Tell your doctor right away if you notice possible mood changes, agitation, or unusual tiredness in your newborn.
This medication passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.
As Vyvanse and Adderall are both stimulant medication made from mixed salts of amphetamine, the side effects of each drug are similar and include:
More serious but rarer side effects include increased heart rate, high blood pressure, hallucinations, paranoia, shortness of breath, heart attack, or stroke. If you experience these or any other side effects, contact a doctor as soon as possible.
There are some additional side effects that need to be considered for women and men.
Men might experience an additional side effect when taking an amphetamine, which is erectile dysfunction (ED). Although you might feel embarrassed to talk about this with your doctor, they will be able to work with you to help resolve this issue.
Adderall and Vyvanse are category C drugs, which means they could be unsafe to an unborn baby. If you are a woman who is pregnant, planning to become pregnant or breastfeeding, talk with your doctor.
Both drugs have the potential to interact with other medications you are taking. Some examples include monoamine oxidases inhibitors (MAOIs), acidifying agents, alkalizing agents, antidepressants, antihistamines and high blood pressure medication. Remember to inform your prescribing doctor about other prescription medication, over- the- counter medication as well as any natural supplements you might be takings
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