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DESOXYN® (methamphetamine hydrochloride tablets, USP), chemically known as (S)-N,α-dimethylbenzeneethanamine hydrochloride, is a member of the amphetamine group of sympathomimetic amines
Desoxyn (methamphetamine hydrochloride tablets, USP
DESOXYN tablets contain 5 mg of methamphetamine hydrochloride for oral administration.
This medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Methamphetamine belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.
This medication is also used along with a doctor-approved, reduced-calorie diet as an aid to help significantly overweight (obese) people lose weight. It should only be used for a short time (a few weeks) in patients who have not lost enough weight with other treatments (e.g., dieting, other drugs, group programs). It may work by decreasing your appetite.
This medication should not be used to treat tiredness or to hold off sleep in people who do not have a sleep disorder.
How to use Desoxyn
Read the Medication Guide provided by your pharmacist before you start using methamphetamine and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
For ADHD, take this medication by mouth with or without food, usually once or twice daily or as directed by your doctor. During treatment, your doctor may occasionally recommend stopping the medication for a short time to see whether there are any changes in your behavior and whether the medication is still needed.
For weight loss, take this medication by mouth, usually half an hour before each meal or as directed by your doctor. Take this medication exactly as prescribed.
Do not take this medication late in the evening because it may cause you to have trouble sleeping.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as extreme tiredness, mental/mood changes such as agitation or depression) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed.
When used for an extended period, this medication may not work as well and may require different dosing (if taken for ADHD) or stopping the medication (if taken for weight loss). Talk with your doctor if this medication stops working well.
Inform your doctor if your condition persists or worsens.
Insulin requirements in diabetes mellitus may be altered in association with the use of methamphetamine and the concomitant dietary regimen.
Methamphetamine may decrease the hypotensive effect of guanethidine.
DESOXYN should not be used concurrently with monoamine oxidase inhibitors
Concurrent administration of tricyclic antidepressants and indirect-acting sympathomimetic amines such as the amphetamines, should be closely supervised and dosage carefully adjusted.
Phenothiazines are reported in the literature to antagonize the CNS stimulant action of the amphetamines.
Drug Abuse And Dependence
Controlled Substance: DESOXYN tablets are subject to control under DEA schedule II.
Methamphetamine has been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with methamphetamine include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis often clinically indistinguishable from schizophrenia. Abuse and/or misuse of methamphetamine have resulted in death. Fatal cardiorespiratory arrest has been reported in the context of abuse and/or misuse of methamphetamine.
DOSAGE FOR DESOXYN
As with all medications, follow your Desoxyn prescription instructions exactly. When treating ADHD, Desoxyn is taken orally, once or twice daily. When treating obesity, Desoxyn is typically taken a half hour before each meal. Taking Desoxyn late in the evening can cause difficulty sleeping. Tablets are available in 5mg dosages.
The optimal dosage varies by patient; it is not determined by age, weight, or height, but rather by how a person metabolizes the medication.
Your doctor may adjust your prescribed dose of Desoxyn until you or your child experiences the best response – that is, the lowest dosage at which you experience the greatest improvement in symptoms without side effects. If you or your child exceeds the prescribed daily dosage, call your doctor or poison control, or seek emergency medical care.
During treatment, your doctor may periodically ask you to stop taking your Desoxyn so that he or she can monitor ADHD symptoms; check vital statistics including heart, and blood pressure; or evaluate height and weight. If any problems are found, your doctor may recommend discontinuing treatment.
After long-term usage, some patients develop a tolerance to Desoxyn. If you notice that your current dosage is no longer controlling symptoms, talk to your doctor to plan a course of action.
General: DESOXYN tablets should be used with caution in patients with even mild hypertension.
Methamphetamine should not be used to combat fatigue or to replace rest in normal persons.
Prescribing and dispensing of methamphetamine should be limited to the smallest amount that is feasible at one time in order to minimize the possibility of overdosage.
Information for Patients: The patient should be informed that methamphetamine may impair the ability to engage in potentially hazardous activities, such as, operating machinery or driving a motor vehicle.
Circulation problems in fingers and toes [Peripheral vasculopathy, including Raynaud’s phenomenon]
Instruct patients beginning treatment with DESOXYN about the risk of peripheral vasculopathy, including Raynaud’s Phenomenon, and associated signs and symptoms: fingers or toes may feel numb, cool, painful, and/or may change color from pale, to blue, to red.
Instruct patients to report to their physician any new numbness, pain, skin color change, or sensitivity to temperature in fingers or toes.
Instruct patients to call their physician immediately with any signs of unexplained wounds appearing on fingers or toes while taking DESOXYN.
Further clinical evaluation (e.g., rheumatology referral) may be appropriate for certain patients.
The patient should be cautioned not to increase dosage, except on advice of the physician.
Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with methamphetamine and should counsel them in its appropriate use. A patient Medication Guide is available for DESOXYN. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have.
SIDE EFFECTS OF DESOXYN
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:signs of heart problems–chest pain, trouble breathing, feeling like you might pass out;
signs of psychosis–hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
signs of circulation problems–numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;a seizure (convulsions);muscle twitches (tics); or changes in your vision.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Desoxyn can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using Desoxyn.
Common side effects may include:headache or dizziness;fast heartbeats;sleep problems (insomnia);diarrhea, constipation, upset stomach;tremors; or loss of appetite, weight loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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